(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Base Information

Chemical Name:(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one
CAS No.:81426-86-0
Molecular Formula:C₃₄H₄₂O₄S
Molecular Weight:546.771
Hs Code.:

(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Synonyms:(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

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Chemical Property of (R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

There total 5 articles about (R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81426-85-9
C₄₆H₇₄O₆SSi₂

: 81426-86-0
(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In benzene; at 60 ℃; Yield given;
DOI:10.1016/S0040-4039(00)85697-X

Reference yield:

: 81874-42-2
C₃₄H₅₆O₅Si

: 81426-86-0
(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: m-CPBA / CHCl₃

2: imidazole / dimethylformamide

3: pyridinium dichromate / dimethylformamide

4: 37 percent / Al₂O₃ / diethyl ether

5: p-toluenesulfonic acid hydrate (p-TsOH_.H₂O) / benzene / 60 °C

With 1H-imidazole; aluminum oxide; dipyridinium dichromate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)85697-X

Reference yield:

: (R)-6-{(S)-1-[(1S,3S,5R,6S,8S,9S,10S,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-17-yl]-ethyl}-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

: 81426-86-0
(R)-6-[(S)-1-((6R,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-oxo-6-phenylsulfanyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-hydroxymethyl-4-methyl-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: pyridinium dichromate / dimethylformamide

3: 37 percent / Al₂O₃ / diethyl ether

4: p-toluenesulfonic acid hydrate (p-TsOH_.H₂O) / benzene / 60 °C

With 1H-imidazole; aluminum oxide; dipyridinium dichromate; toluene-4-sulfonic acid; In diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)85697-X