Technology Process of 4-((2-(thiophen-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl)oxy)aniline
There total 4 articles about 4-((2-(thiophen-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl)oxy)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / 120 h / 0 - 4 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Inert atmosphere
2.2: 20 h / 70 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 20 °C
4.1: ethanol; calcium chloride; zinc / 1 h / Reflux
5.1: polyphosphoric acid / 4 h / 250 °C
With
ethanol; sulfuric acid; potassium tert-butylate; nitric acid; sodium hydrogencarbonate; calcium chloride; zinc;
In
1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200120
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Inert atmosphere
1.2: 20 h / 70 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 20 °C
3.1: ethanol; calcium chloride; zinc / 1 h / Reflux
4.1: polyphosphoric acid / 4 h / 250 °C
With
ethanol; potassium tert-butylate; sodium hydrogencarbonate; calcium chloride; zinc;
In
1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200120