1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene

Base Information

• Chemical Name: 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene
• CAS No.: 173204-75-6
• Molecular Formula: C₂₀H₃₂O₂
• Molecular Weight: 304.473
• Mol file: 173204-75-6.mol

Synonyms:1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene

Chemical Property of 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene

There total 2 articles about 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3R,4R)-3-methylundec-1-en-4-ol (173326-39-1) + 2,2,2-Trichloro-N-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-acetamide → 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene (173204-75-6)

Guidance literature:

With trifluorormethanesulfonic acid; In tetrahydrofuran; at 25 ℃; for 5h;

DOI:10.1021/jo9608329

Reference yield:

Octanal (124-13-0) → 1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene (173204-75-6)

Guidance literature:

Multi-step reaction with 2 steps

2: 80 percent / TfOH / tetrahydrofuran / 5 h / 25 °C

With trifluorormethanesulfonic acid; In tetrahydrofuran;

DOI:10.1021/jo9608329

Reference yield:

1-Methoxy-4-[(R)-1-((R)-1-methyl-allyl)-octyloxymethyl]-benzene (173204-75-6) → (S)-1-carboxy-2-methylpropyl (2S,3R)-3-p-<(methoxybenzyl)oxy>-2-methyldecanoate (173204-70-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) O₃, 2) PPh₃ / 1) CH₂Cl₂, -78 deg C, 8 min, 2) CH₂Cl₂, 25 deg C, overnight

2: 100 percent / NaClO₂, 2-methyl-2-butene, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 25 °C

3: SOCl₂, i-Pr₂NEt / CH₂Cl₂ / 2 h / 0 °C

4: i-Pr₂NEt / CH₂Cl₂ / 25 °C

With sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jo9608329

upstream raw materials:

(3R,4R)-3-methylundec-1-en-4-ol

Octanal

Downstream raw materials:

(2S,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-decanal

(-)-hapalosin

(2S,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-decanoyl chloride

(2S,3R)-3-p-<(methoxybenzyl)oxy>-2-methyldecanoic acid