benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate

Base Information

• Chemical Name: benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate
• CAS No.: 888472-81-9
• Molecular Formula: C₈₃H₁₂₂FO₂₁P₃
• Molecular Weight: 1567.79
• Mol file: 888472-81-9.mol

Synonyms:benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate

Chemical Property of benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate

There total 1 articles about benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-dihydroxy-1-fluoro-1-buten-1-yl)phosphonate (888472-80-8) + 1-hexadecylcarboxylic acid (57-10-3) → benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate (888472-81-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/ja060621d

Reference yield: 87.5%

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate (888472-81-9) → 1-[2,3,6-O-tris(hydroxyl)-4,5-O-bis(diphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonic acid

Guidance literature:

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate; With trimethylsilyl bromide; trimethylsilyl iodide; at 20 ℃; for 1.5h;

With methanol; for 1h;

DOI:10.1021/ja060621d

Reference yield: 57.0%

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate (888472-81-9) → 1-[2,3,6-O-tris(hydroxyl)-4,5-O-bis(diphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-butyl)phosphonic acid

Guidance literature:

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dipalmitoyl-1-fluoro-1-buten-1-yl)phosphonate; With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 760 Torr;

With ethanethiol; for 1.5h;

DOI:10.1021/ja060621d

upstream raw materials:

benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-dihydroxy-1-fluoro-1-buten-1-yl)phosphonate

1-hexadecylcarboxylic acid