2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate

Base Information

• Chemical Name: 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate
• CAS No.: 1243680-44-5
• Molecular Formula: C₂₇H₃₀ClNO₆
• Molecular Weight: 499.991

Synonyms:2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate

Chemical Property of 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate

Chemical Property:

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Technology Process of 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate

There total 1 articles about 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-iodophenyl acetate (1243680-43-4) + N-tert-Butoxycarbonyl-1-amino-3-propyne (92136-39-5) → 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate (1243680-44-5)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; for 17h;

DOI:10.1016/j.bmc.2010.06.017

Reference yield: 100.0%

2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate (1243680-44-5) → 2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)propyl)phenyl acetate (1243680-48-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 72h;

DOI:10.1016/j.bmc.2010.06.017

Reference yield:

2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)prop-1-ynyl)phenyl acetate (1243680-44-5) → C22H22ClNO4 (1243680-46-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2010.06.017

upstream raw materials:

2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-iodophenyl acetate

N-tert-Butoxycarbonyl-1-amino-3-propyne

Downstream raw materials:

2-(2-acetoxy-5-(2-chloroethyl)benzyl)-4-(3-(tert-butoxycarbonylamino)propyl)phenyl acetate

C₂₂H₂₂ClNO₄

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