(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester
CAS No.:790302-29-3
Molecular Formula:C₂₉H₅₀N₂O₇Si
Molecular Weight:566.811
Hs Code.:

(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Synonyms:(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Suppliers and Price of (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

There total 11 articles about (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53363-91-0
2-(N-benzyloxycarbonyl-N-methylamino)-3-methylbutyric acid methyl ester

: 790302-29-3
(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl; H₂ / Pd/C / methanol / 4 h / 20 °C

2: iPr₂NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH₂Cl₂ / -25 - 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ol048437p

Reference yield:

: 35016-37-6,769890-37-1
N-methyl-L-valine methyl ester

: (2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoic acid

: 790302-29-3
(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -25 - 20 ℃;
DOI:10.1021/ol048437p

Reference yield:

: 7274-88-6,26124-78-7
D-lysine hydrochloride

: 790302-29-3
(S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: aq. LiOH / 0 °C

2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C

2.2: HCl / ethanol / 0.17 h / 50 °C

3.1: NaNO₂; AcOH / 6 h / 40 °C

4.1: Et₃N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C

4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C

5.1: PhCO₂Ag; Et₃N / -25 - 20 °C

6.1: K₂CO₃ / methanol / 6 h / 0 °C

7.1: iPr₂NEt / CH₂Cl₂ / 5 h / 20 °C

8.1: LDA; LiCl / tetrahydrofuran / -78 °C

9.1: LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 0 - 20 °C

10.1: iPr₂NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH₂Cl₂ / -25 - 20 °C

With lithium hydroxide; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; silver benzoate; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium diisopropyl amide; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/ol048437p