2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Base Information

Chemical Name:2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester
CAS No.:301844-17-7
Molecular Formula:C₁₈H₁₉NO₃S
Molecular Weight:329.42
Hs Code.:

2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2<i>H</i>-pyridin-1-yl ester

Synonyms:2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

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Chemical Property of 2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

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Technology Process of 2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

There total 7 articles about 2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-72-1
Tetrahydropyran-2-methanol

: 301844-17-7
2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: TEMPO; Aliquat 336; KBr / NaOCl / CH₂Cl₂; H₂O / 20 °C

2.1: 15.71 g / acetyl chloride / CH₂Cl₂; H₂O / 2 h / Heating

3.1: diisopropyl amine; n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 83 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: isopropylmagnesium bromide / tetrahydrofuran / -20 - 20 °C

5.1: 91 percent / ammonia; sodium; ethanol / tetrahydrofuran / 1 h / -78 °C

6.1: 100 percent / NaOH / ethane-1,2-diol; H₂O / 13 h / Heating

7.1: DIPDI; DMAP / dodecane / 2.5 h / 0 - 20 °C

With dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; n-butyllithium; ethanol; ammonia; isopropylmagnesium bromide; sodium; Aliquat 336; diisopropylamine; acetyl chloride; potassium bromide; sodium hypochlorite; In tetrahydrofuran; dodecane; hexane; dichloromethane; water; ethylene glycol;
DOI:10.1021/ja002068k

Reference yield:

: 1121-30-8
1-hydroxy-2(1H)-pyridinethione

: 301844-14-4
(S)-(-)-2-benzyl-tetrahydro-pyran-2-carboxylic acid

: 301844-17-7
2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: With dmap; In dodecane; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/ja002068k

Reference yield:

: 301844-19-9
2-benzyl-2-carboethoxy-tetrahydro-pyran

: 301844-17-7
2-benzyl-tetrahydro-pyran-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: isopropylmagnesium bromide / tetrahydrofuran / -20 - 20 °C

2: 91 percent / ammonia; sodium; ethanol / tetrahydrofuran / 1 h / -78 °C

3: 100 percent / NaOH / ethane-1,2-diol; H₂O / 13 h / Heating

4: DIPDI; DMAP / dodecane / 2.5 h / 0 - 20 °C

With dmap; sodium hydroxide; ethanol; ammonia; isopropylmagnesium bromide; sodium; In tetrahydrofuran; dodecane; water; ethylene glycol;
DOI:10.1021/ja002068k