(S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate

Base Information

• Chemical Name: (S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate
• CAS No.: 1393113-86-4
• Molecular Formula: C₄₄H₅₀N₂O₈
• Molecular Weight: 734.89

Synonyms:(S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate

Chemical Property of (S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate

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Technology Process of (S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate

There total 1 articles about (S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

(R)-tert-butyl-2-(3-(1-amino-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetate (1373829-43-6) + (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (101555-63-9,105751-19-7,86069-86-5) → (S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate (1393113-86-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield: 84.0%

(S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate (1393113-86-4) → C40H42N2O8 (1373829-45-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jm201747c

Reference yield: 53.1%

(S)-1-((9H-fluoren-9-yl)methyl)ester-2-((R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-2-carboxylate (1393113-86-4) → tert-butyl-2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-piperidine-2-carboxamido)propyl)phenoxy) acetate

Guidance literature:

With 4-methylpiperidin; In dichloromethane; for 14h;

upstream raw materials:

(R)-tert-butyl-2-(3-(1-amino-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetate

(S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Downstream raw materials:

C₄₀H₄₂N₂O₈

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