(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

Base Information

Chemical Name:(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride
CAS No.:1526901-56-3
Molecular Formula:C₂₁H₂₂N₂O₃*ClH
Molecular Weight:386.878
Hs Code.:

Synonyms:(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

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Chemical Property of (S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

Chemical Property:

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Technology Process of (S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

There total 7 articles about (S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1526901-52-9
(S,E)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3yl)propoxy)phenyl)acrylate

: 1526901-56-3
(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;
DOI:10.1021/jm401877m

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1526901-56-3
(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: acetyl chloride / 5 h / 0 - 75 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 °C

3: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; acetyl chloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; 2: |Mitsunobu Displacement;
DOI:10.1021/jm401877m

Reference yield:

: 3943-97-3
methyl 4-hydroxycinnamate

: 1526901-56-3
(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 °C

2: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; 1: |Mitsunobu Displacement;
DOI:10.1021/jm401877m