(2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one

Base Information

• Chemical Name: (2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one
• CAS No.: 1231766-04-3
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• Mol file: 1231766-04-3.mol

Synonyms:(2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one

Chemical Property of (2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one

There total 1 articles about (2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(R)-5-phenyl-3-(7-(trimethylsilyl)hept-5-enyl)-5,6-dihydro-2H-1,4-oxazin-2-one → C17H21NO2 + (2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one (1231766-04-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol1010246

Reference yield: 92.0%

(2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one (1231766-04-3) → (1R,2R)-1-amino-2-ethylcyclohexanecarboxylic acid (1231766-05-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 16h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/ol1010246

Reference yield:

(2R,6R,7S)-2-phenyl-7-vinyl-1-aza-4-oxaspiro[5.5]undecan-5-one (1231766-04-3) → C17H23NO3

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 3h; Inert atmosphere;

DOI:10.1021/ol1010246

Downstream raw materials:

(1R,2R)-1-amino-2-ethylcyclohexanecarboxylic acid