trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester

Base Information

• Chemical Name: trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester
• CAS No.: 248275-65-2
• Molecular Formula: C₁₃H₁₁F₅O₃S
• Molecular Weight: 342.287

Synonyms:trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester

Chemical Property of trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester

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Technology Process of trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester

There total 5 articles about trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Cyclopent-3-enylmethyl-3,4-difluoro-phenol (248275-64-1) + trifluoromethylsulfonic anhydride (358-23-6) → trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester (248275-65-2)

Guidance literature:

With pyridine;

DOI:10.1021/ol0623062

Reference yield:

(3-cyclopenten-1-yl)-methanone (20145-35-1) → trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester (248275-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 2 h / -78 °C

1.2: 40 percent / tetrahydrofuran / -78 °C

2.1: 59 percent / TFA; Et₃SiH

3.1: 96 percent / BCl₃; nBu₄NI

4.1: 81 percent / pyridine

With pyridine; triethylsilane; boron trichloride; tetra-(n-butyl)ammonium iodide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/ol0623062

Reference yield:

1,2-difluoro-4-methoxy-benzene (115144-40-6) → trifluoro-methanesulfonic acid 2-cyclopent-3-enylmethyl-3,4-difluoro-phenyl ester (248275-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 2 h / -78 °C

1.2: 40 percent / tetrahydrofuran / -78 °C

2.1: 59 percent / TFA; Et₃SiH

3.1: 96 percent / BCl₃; nBu₄NI

4.1: 81 percent / pyridine

With pyridine; triethylsilane; boron trichloride; tetra-(n-butyl)ammonium iodide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/ol0623062

upstream raw materials:

2-Cyclopent-3-enylmethyl-3,4-difluoro-phenol

trifluoromethylsulfonic anhydride

2-Cyclopent-3-enylmethyl-3,4-difluoro-1-methoxy-benzene

cyclopent-3-enyl-(2,3-difluoro-6-methoxy-phenyl)-methanol

Downstream raw materials:

(+)-N-benzyl-5,6-difluoro-11-azatricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene

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