2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

Base Information

• Chemical Name: 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine
• CAS No.: 34164-94-8
• Molecular Formula: C₁₃H₁₀ClN₃
• Molecular Weight: 243.695
• Mol file: 34164-94-8.mol

Synonyms:2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

Chemical Property of 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

Chemical Property:

• Melting Point: 146-148 °C
• PKA: 7.68±0.50(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

There total 6 articles about 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-aminopyridine (504-29-0) + tert-butylisonitrile (119072-55-8,7188-38-7) + 4-chlorobenzaldehyde (104-88-1) → 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine (34164-94-8)

Guidance literature:

2-aminopyridine; tert-butylisonitrile; 4-chlorobenzaldehyde; With zirconium(IV) chloride; In butan-1-ol; at 140 ℃; for 0.116667h; Microwave irradiation;

With tetrafluoroboric acid; In butan-1-ol; at 160 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/jm200235u

Reference yield: 72.0%

N?(tert?butyl)?2?(4?chlorophenyl)imidazo[1,2?a]pyridin?3?amine (601468-08-0) → 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine (34164-94-8)

Guidance literature:

With 4-methoxy-benzaldehyde; trifluoroacetic acid; In 1,2-dichloro-ethane; Reflux;

DOI:10.1021/jo202255v

Reference yield:

N-(4-chlorobenzylidene)[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]amine (1323381-60-7) → 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine (34164-94-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1002/jhet.518

upstream raw materials:

N-2-(2,4,4-trimethylpentan-2-yl) 2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

N?(tert?butyl)?2?(4?chlorophenyl)imidazo[1,2?a]pyridin?3?amine

N-(4-chlorobenzylidene)[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]amine

2-aminopyridine

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