(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

Base Information

Chemical Name:(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate
CAS No.:1192040-44-0
Molecular Formula:C₃₆H₄₂N₂O₄
Molecular Weight:566.74
Hs Code.:

Synonyms:(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

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Chemical Property of (+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

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Technology Process of (+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

There total 9 articles about (+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1192040-43-9
(+/-)-tert-Butyl 3-[3-({[4-(aminomethyl)phenyl] (cyclopentyl)acetyl}amino)-2-methyl-phenyl]propanoate

: 643-79-8
o-phthalic dicarboxaldehyde

: 1192040-44-0
(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

Guidance literature:: With acetic acid; at 20 ℃; for 1h;

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1192040-44-0
(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 36 h / 125 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

3: pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: hydrazine hydrate / ethanol / Reflux

5: acetic acid / 1 h / 20 °C

With pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; hydrogen; hydrazine hydrate; acetic acid; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1192040-44-0
(+/-)-tert-Butyl 3-{3-[(cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-acetyl)amino]-2-methylphenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 36 h / 125 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

3: pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: hydrazine hydrate / ethanol / Reflux

5: acetic acid / 1 h / 20 °C

With pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; hydrogen; hydrazine hydrate; acetic acid; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;