2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

Base Information

Chemical Name:2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine
CAS No.:121654-79-3
Molecular Formula:C₂₀H₂₆N₂OS
Molecular Weight:342.505
Hs Code.:

Synonyms:2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

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Chemical Property of 2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

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Technology Process of 2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

There total 9 articles about 2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 98123-67-2,98123-83-2,98123-66-1,121654-56-6
2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benzazepine

: 121654-79-3
2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

Guidance literature:: With Lawessons reagent; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 80 ℃; for 3h;
DOI:10.1021/jm00129a007

Reference yield: 16.0%

: 121654-86-2,98123-57-0
2H-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

: 2719-27-9
cyclohexanylcarbonyl chloride

: 121654-79-3
2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

Guidance literature:: With triethylamine; In chloroform; 1) 0 deg C, 30 min, 2) r.t., 5 h;
DOI:10.1021/jm00129a007

Reference yield:

: 2038-57-5
3-Phenylpropan-1-amine

: 121654-79-3
2-(cyclohexylcarbonyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / 1 h / Heating

2: 81 percent / NaBH₄, NaHCO₃ / ethanol; H₂O / 1 h / 5 °C

3: 32 percent / polyphosphoric acid / 0.75 h / 180 °C

4: 61 percent / H₂ / Pd-C / ethanol / 45 °C / 760 Torr

5: 100 percent / NEt₃ / CHCl₃ / 1) 0 deg C, 30 min, 2) r.t., 90 min

6: Lawesson's reagent / hexamethylphosphoric acid triamide / 3 h / 80 °C

7: conc. HCl / acetone / 0.5 h / Ambient temperature

8: 16 percent / NEt₃ / CHCl₃ / 1) 0 deg C, 30 min, 2) r.t., 5 h

With Lawessons reagent; hydrogenchloride; sodium tetrahydroborate; PPA; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; chloroform; water; acetone;
DOI:10.1021/jm00129a007