4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

Base Information

Chemical Name:4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide
CAS No.:1346459-80-0
Molecular Formula:C₂₀H₉ClF₇NO
Molecular Weight:447.739
Hs Code.:

Synonyms:4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

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Chemical Property of 4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

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Technology Process of 4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

There total 4 articles about 4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1300857-08-2
3-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 1346459-80-0
4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

Guidance literature:: With water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tert-Amyl alcohol; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1246/cl.2011.1004

Reference yield:

: 434-64-0
perfluorotoluene

: 1346459-80-0
4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane; water / 80 °C

2: toluene / 28 h / 20 °C / Reflux

3: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tert-Amyl alcohol / 12 h / 100 °C / Inert atmosphere

With ammonia; water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In 1,4-dioxane; tert-Amyl alcohol; water; toluene;
DOI:10.1246/cl.2011.1004

Reference yield:

: 535-80-8
3-chlorobenzoate

: 1346459-80-0
4-chloro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2: toluene / 28 h / 20 °C / Reflux

3: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tert-Amyl alcohol / 12 h / 100 °C / Inert atmosphere

With thionyl chloride; water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tert-Amyl alcohol; toluene;
DOI:10.1246/cl.2011.1004