C₅₃H₆₂F₂N₈O₇

Base Information

• Chemical Name: C₅₃H₆₂F₂N₈O₇
• CAS No.: 1612854-12-2
• Molecular Formula: C₅₃H₆₂F₂N₈O₇
• Molecular Weight: 961.121
• Mol file: 1612854-12-2.mol

Synonyms:C₅₃H₆₂F₂N₈O₇

Chemical Property of C₅₃H₆₂F₂N₈O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₆₂F₂N₈O₇

There total 22 articles about C₅₃H₆₂F₂N₈O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C35H40F4N4O6S (1612854-07-5) + C25H34BFN4O6 (1612854-11-1) → C53H62F2N8O7 (1612854-12-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (203866-16-4) → C53H62F2N8O7 (1612854-12-2)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium hydroxide; water / tetrahydrofuran / 2 h / 0 - 20 °C

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

5: lithium hydroxide; water / dichloromethane / 5 h / 0 - 20 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

7: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4,7-dimethoxyindan-1-one (52428-09-8) → C53H62F2N8O7 (1612854-12-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium tert-butylate / toluene / 2.5 h / 0 - 110 °C / Inert atmosphere

2.1: trifluoroacetic acid; triethylsilane / 7 h / 0 - 40 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 1.16 h / -78 - 20 °C

4.1: pyridine / dichloromethane / 0.02 h / 0 °C

4.2: 1 h / 0 - 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

With pyridine; triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; potassium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; water; toluene;

upstream raw materials:

2,5-dimethoxybenzaldehyde

3-(2,5-dimethoxyphenyl)propanoic acid

4,7-dimethoxyindan-1-one

C₁₆H₂₀O₃