5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

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Chemical Name:5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride
CAS No.:138965-44-3
Molecular Formula:C₃₁H₃₆N₈O₇*2ClH
Molecular Weight:705.598
Hs Code.:

5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

Synonyms:5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

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Chemical Property of 5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

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Technology Process of 5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

There total 9 articles about 5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 138965-43-2
{(S)-1-[3-({[({[(Hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: 138965-44-3
5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; for 0.5h; Ambient temperature;
DOI:10.1016/0223-5234(91)90119-8

Reference yield:

: 1975-52-6
5-nitro-o-toluic acid

: 138965-44-3
5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: AcCl / Heating

2: N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 20 h / Heating

3: NaOH, tricaprylmethylammonium chloride / CH₂Cl₂; H₂O / 5 h / Ambient temperature

4: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature

5: SOCl₂, DMF / 3 h / Ambient temperature

6: Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h

7: H₂ / PtO₂ / dimethylformamide; H₂O / 2 h / Ambient temperature

8: dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

9: 89 percent / H₂NNH₂*H₂O / methanol / 24 h / Ambient temperature

10: 96 percent / 2 M HCl / acetic acid / 0.5 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; hydrogen; Aliquat 336; hydrazine hydrate; triethylamine; acetyl chloride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90119-8

Reference yield:

: 77324-87-9
methyl 2-methyl-5-nitrobenzoate

: 138965-44-3
5-((S)-2-Amino-3-phenyl-propionylamino)-N-{[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-2-phenoxymethyl-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 20 h / Heating

2: NaOH, tricaprylmethylammonium chloride / CH₂Cl₂; H₂O / 5 h / Ambient temperature

3: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature

4: SOCl₂, DMF / 3 h / Ambient temperature

5: Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h

6: H₂ / PtO₂ / dimethylformamide; H₂O / 2 h / Ambient temperature

7: dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

8: 89 percent / H₂NNH₂*H₂O / methanol / 24 h / Ambient temperature

9: 96 percent / 2 M HCl / acetic acid / 0.5 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; hydrogen; Aliquat 336; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90119-8