5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine
CAS No.:1560795-87-0
Molecular Formula:C₂₂H₂₁N₃O₄S
Molecular Weight:423.492
Hs Code.:

Synonyms:5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

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Chemical Property of 5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

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Technology Process of 5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

There total 5 articles about 5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethynyl]-5H-pyrrolo[2,3-b]pyrazine

: 1560795-87-0
5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: With hydrogen; In ethanol; water; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 5-(benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1560795-87-0
5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 88 °C

2: palladium on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C / 2327.23 Torr

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated carbon; hydrogen; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1560795-87-0
5-(benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 1 h

2.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 88 °C

3.1: palladium on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C / 2327.23 Torr

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; water; mineral oil;