(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

Base Information

Chemical Name:(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione
CAS No.:1311136-97-6
Molecular Formula:C₁₈H₂₀N₄O₄
Molecular Weight:356.381
Hs Code.:

Synonyms:(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

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Chemical Property of (5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

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Technology Process of (5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

There total 8 articles about (5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1311138-49-4
(2R)-2-amino-N-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)butanamide

: 1311136-97-6
(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 5428-54-6
2-methyl-5-nitrophenol

: 1311136-97-6
(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 48 h / Reflux

2.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

3.1: water; sodium nitrite; sulfuric acid / 2.75 h / 0 - 90 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 48 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

8.1: triethylamine / dichloromethane / 0.33 h / 0 °C

With sulfuric acid; water; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium nitrite; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 676224-74-1
3-ethoxy-4-methyl-phenol

: 1311136-97-6
(5R)-5-ethyl-3-(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 48 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C

With water; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;