3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel
CAS No.:926306-81-2
Molecular Formula:C₄₂H₅₂F₃NO₁₅
Molecular Weight:867.868
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

Chemical Property:

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Technology Process of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

There total 8 articles about 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₇H₈₆F₃NO₁₅Si₂

: 926306-81-2
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 926306-81-2
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

3: diisopropyl-carbodiimide; dmap / dichloromethane

4: pyridine; hydrogen fluoride / acetonitrile

5: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6: lithium hexamethyldisilazane / tetrahydrofuran

7: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

8: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 926306-81-2
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-fluorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 7 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane

3: pyridine; hydrogen fluoride / acetonitrile

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran

6: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

7: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007