(S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate
• CAS No.: 1615254-55-1
• Molecular Formula: C₂₁H₂₁BrFN₃O₃
• Molecular Weight: 462.318

Synonyms:(S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Chemical Property of (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

There total 1 articles about (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (1615254-55-1)

Guidance literature:

With pyridine; diphenyl phosphite; at 40 ℃; for 2h;

at 55 ℃; for 12h;

Reference yield:

mercaptoethyl alcohol (129976-27-8) + (S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (1615254-55-1) → (S)-tert-butyl (1-(3-(3-fluorophenyl)-5-((2-hydroxyethyl)thio)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; L-proline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 18h; Sealed tube;

Reference yield:

(S)-tert-butyl (1-(5-bromo-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (1615254-55-1) → (S)-tert-butyl (1-(3-(3-fluorophenyl)-5-((2-hydroxyethyl)thio)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; L-proline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 100 °C / Sealed tube

2: oxone / tetrahydrofuran; water / 20 °C

With oxone; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; L-proline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

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