6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:138491-15-3
Molecular Formula:C₃₄H₃₄F₃NO₅
Molecular Weight:593.643
Hs Code.:

Synonyms:6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

There total 11 articles about 6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138491-10-8
N-<2-<3,4-bis(benzyloxy)-2-(trifluoromethyl)phenyl>ethyl>-3',4',5'-trimethoxyphenylacetamide

: 138491-15-3
6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus oxychloride / acetonitrile / 5 h / Heating

2: sodium borohydride / methanol / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1021/jm00081a007

Reference yield:

: 621-59-0
isovanillin

: 138491-15-3
6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 12 steps

1: 73 percent / pyridine, iodine monochloride / dioxane / 144 h / Ambient temperature

2: 85 percent / potassium carbonate / acetone / 6 h / Heating

3: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C

4: 87 percent / sodium borohydride / tetrahydrofuran; H₂O / 2.5 h / 40 °C

5: 73.5 percent / phosphorus tribromide / CH₂Cl₂ / 2 h / 0 °C

6: 92 percent / dimethylformamide / 0.5 h / Ambient temperature

7: 82 percent / boron tribromide / CH₂Cl₂ / Ambient temperature

8: 86 percent / potassium carbonate, potassium iodide / acetone / Heating

9: diborane / tetrahydrofuran / Heating

10: toluene / 72 h / Heating

11: phosphorus oxychloride / acetonitrile / 5 h / Heating

12: sodium borohydride / methanol / Ambient temperature

With pyridine; sodium tetrahydroborate; copper(l) iodide; Iodine monochloride; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; diborane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007

Reference yield:

: 138490-95-6
2-iodo-3,4-dimethoxybenzaldehyde

: 138491-15-3
6,7-bis(benzyloxy)-1-(3',4',5'-trimethoxybenzyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C

2: 87 percent / sodium borohydride / tetrahydrofuran; H₂O / 2.5 h / 40 °C

3: 73.5 percent / phosphorus tribromide / CH₂Cl₂ / 2 h / 0 °C

4: 92 percent / dimethylformamide / 0.5 h / Ambient temperature

5: 82 percent / boron tribromide / CH₂Cl₂ / Ambient temperature

6: 86 percent / potassium carbonate, potassium iodide / acetone / Heating

7: diborane / tetrahydrofuran / Heating

8: toluene / 72 h / Heating

9: phosphorus oxychloride / acetonitrile / 5 h / Heating

10: sodium borohydride / methanol / Ambient temperature

With sodium tetrahydroborate; copper(l) iodide; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; diborane; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007