(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

Base Information

Chemical Name:(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran
CAS No.:1362101-08-3
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:

Synonyms:(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

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Chemical Property of (+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

Chemical Property:

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Technology Process of (+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

There total 4 articles about (+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1362100-85-3
(+/-)-2-(1H-tetrazol-5-yl)-1-(3,4,5-trimethoxybenzyloxy)propan-2-ol

: 1362101-08-3
(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

Guidance literature:: With diisopropyl-carbodiimide; In 1,2-dichloro-ethane; at 84 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300276p

Reference yield:

: 1,2,3-trimethoxy-5-{[(prop-2-yn-1-yl)oxy]methyl}benzene

: 1362101-08-3
(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; mercury(II) trifluoroacetate / acetone / 20 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere

2.2: 2 h / -98 - -60 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: diisopropyl-carbodiimide / 1,2-dichloro-ethane / 1 h / 84 °C / Inert atmosphere

With n-butyllithium; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; N,N,N,N,-tetramethylethylenediamine; tert-butylmagnesium chloride; water; mercury(II) trifluoroacetate; diisopropyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/ol300276p

Reference yield:

: 1362100-73-9
(+/-)-2-(1-allyl-1H-tetrazol-5-yl)-1-(3,4,5-trimethoxybenzyloxy)propan-2-ol

: 1362101-08-3
(+/-)-4-methyl-2-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: diisopropyl-carbodiimide / 1,2-dichloro-ethane / 1 h / 84 °C / Inert atmosphere

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol300276p