1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

Base Information

Chemical Name:1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one
CAS No.:124608-95-3
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

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Chemical Property of 1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

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Technology Process of 1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

There total 8 articles about 1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 124608-93-1,124608-94-2
trans-1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-1-methylthio-5-phenyl-2H-3-benzazepin-2-one

: 124608-95-3
1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

Guidance literature:: With nickel; In ethanol; for 4h; Heating;
DOI:10.1248/cpb.37.939

Reference yield: 65.0%

: 124608-93-1,124608-94-2
(1S,5R)-7,8-Dimethoxy-3-methyl-1-methylsulfanyl-5-phenyl-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

: 124608-95-3
1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

Guidance literature:: With nickel; In ethanol; for 4h; Heating;
DOI:10.1248/cpb.37.939

Reference yield:

: 17777-02-5
(3,4-dimethoxyphenyl)phenylacetic acid

: 124608-95-3
1,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-5-phenyl-2H-3-benzazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / tetrahydrofuran / 1 h / Heating

2: K₂CO₃ / benzene; H₂O / Ambient temperature

3: 530 mg / borane-THF / tetrahydrofuran / 0 deg C, then 1 h, reflux

4: 53 percent / Et₃N / diethyl ether / 0.5 h / 0 °C

5: 70 percent / NaIO₄ / H₂O; methanol / 15 h / Ambient temperature

6: 26 percent / TFAA / CH₂Cl₂ / 20 h / Ambient temperature

7: 65 percent / Raney Ni / ethanol / 4 h / Heating

With sodium periodate; thionyl chloride; borane-THF; nickel; potassium carbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1248/cpb.37.939