Pyroangolensolide

Base Information

Chemical Name:Pyroangolensolide
CAS No.:25992-11-4
Molecular Formula:C₁₅H₁₆O₃
Molecular Weight:244.29
Hs Code.:
Mol file:25992-11-4.mol

Synonyms:3H-2-Benzopyran-3-one,1-(3-furanyl)-1,7,8,8a-tetrahydro-5,8a-dimethyl-, cis-(+)-;3H-2-Benzopyran-3-one, 1a-(3-furyl)-1,7,8,8a-tetrahydro-5,8aa-dimethyl-, (+)- (8CI); Pyroangolensolide

Suppliers and Price of Pyroangolensolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Pyroangolensolide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyroangolensolide

There total 5 articles about Pyroangolensolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₅H₁₈O₄

: 25992-11-4,52730-11-7,52730-12-8
(+)-pyroangolensolide

Guidance literature:: C₁₅H₁₈O₄; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 4.25h; Inert atmosphere; Sealed tube;

With Burgess Reagent; In tetrahydrofuran; at 60 ℃; for 3h; Inert atmosphere; Sealed tube;
DOI:10.1021/jacs.9b04508

Reference yield:

: 40790-56-5
2,6-dimethyl-2-cyclohexen-1-one

: 25992-11-4,52730-11-7,52730-12-8
(+)-pyroangolensolide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole / toluene / 0.25 h / 0 °C / Inert atmosphere; Resolution of racemate

2.2: 10 h / 0 °C / Inert atmosphere; Resolution of racemate

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 4.25 h / -78 - 20 °C / Inert atmosphere; Sealed tube

3.2: 3 h / 60 °C / Inert atmosphere; Sealed tube

With n-butyllithium; R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole; diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene; 1.1: |Aldol Addition / 1.2: |Aldol Addition / 3.1: |Aldol Addition;
DOI:10.1021/jacs.9b04508

Reference yield:

: 2816-57-1
2,6-dimethylcyclohexanone

: 25992-11-4,52730-11-7,52730-12-8
(+)-pyroangolensolide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -40 - 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

1.3: 5 h / 0 - 60 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole / toluene / 0.25 h / 0 °C / Inert atmosphere; Resolution of racemate

3.2: 10 h / 0 °C / Inert atmosphere; Resolution of racemate

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 4.25 h / -78 - 20 °C / Inert atmosphere; Sealed tube

4.2: 3 h / 60 °C / Inert atmosphere; Sealed tube

With n-butyllithium; R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole; diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene; 2.1: |Aldol Addition / 2.2: |Aldol Addition / 4.1: |Aldol Addition;
DOI:10.1021/jacs.9b04508