3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Base Information

Chemical Name:3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate
CAS No.:1162655-06-2
Molecular Formula:C₇H₈O₃S*C₂₂H₂₆N₂O₂S
Molecular Weight:554.731
Hs Code.:

Synonyms:3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

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Chemical Property of 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

There total 3 articles about 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.76%

: 1196663-24-7
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

: 104-15-4
toluene-4-sulfonic acid

: 1162655-06-2
3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Guidance literature:: (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate; With methanesulfonic acid; hydrogen; palladium 10% on activated carbon; In water; acetone; at 8 - 10 ℃; under 1471.14 - 3677.86 Torr;

With ammonia; In methyl tert-butyl ether (MTBE); water; pH=9.0 - 9.5;

toluene-4-sulfonic acid; In ethanol; at 40 - 45 ℃;

Reference yield: 73.5%

: 180637-89-2
(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

: 104-15-4
toluene-4-sulfonic acid

: 1162655-06-2
3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Guidance literature:: (R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole; With methanesulfonic acid; hydrogen; palladium 10% on activated carbon; In water; acetone; at 8 - 10 ℃;

With ammonia; In water; pH=12;

toluene-4-sulfonic acid; In acetone; at 40 ℃; for 2h; pH=4.5 - 5.0; Product distribution / selectivity;

Reference yield: 60.0%

: 438226-82-5
(R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

: 104-15-4
toluene-4-sulfonic acid

: 1162655-06-2
3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Guidance literature:: (R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole; With methanol; potassium carbonate; In acetone; at 20 - 25 ℃;

toluene-4-sulfonic acid; In acetone; at 35 - 40 ℃;