C₁₇H₁₈O₃

Base Information

• Chemical Name: C₁₇H₁₈O₃
• CAS No.: 1392489-47-2
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 1392489-47-2.mol

Synonyms:C₁₇H₁₈O₃

Chemical Property of C₁₇H₁₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₈O₃

There total 11 articles about C₁₇H₁₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-1-((R)-6-benzyloxychroman-2-yl)ethane-1,2-diol (1392489-46-1) → C17H18O3 (1392489-47-2)

Guidance literature:

(S)-1-((R)-6-benzyloxychroman-2-yl)ethane-1,2-diol; With sodium periodate; water; In methanol; at 0 ℃; for 2h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

4-methoxy-phenol (150-76-5) → C17H18O3 (1392489-47-2)

Guidance literature:

Multi-step reaction with 13 steps

1.1: potassium carbonate / acetonitrile / 20 °C / Reflux

2.1: 16 h / 200 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 6 h / Reflux

4.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C

4.2: 6 h / Reflux

5.1: pyridinium chlorochromate / dichloromethane / 5 h / 0 - 20 °C / Molecular sieve

6.1: dichloromethane / 18 h / 20 °C

7.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere

8.1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 18 h / -25 °C / Molecular sieve

9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

9.2: 3 h / 0 °C

9.3: 0.67 h / 0 - 20 °C

10.1: toluene-4-sulfonic acid / 0.5 h / 20 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

12.1: toluene-4-sulfonic acid; water / methanol / 12 h / Reflux

13.1: sodium periodate; water / methanol / 2 h / 0 °C

13.2: 1 h / 0 - 20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 9-borabicyclo[3.3.1]nonane; pyridinium chlorochromate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; decane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 2.1: Claisen Rearrangement / 6.1: Wittig Reaction / 8.1: Sharpless Epoxidation;

Reference yield:

allyl (4-methoxyphenyl) ether (13391-35-0) → C17H18O3 (1392489-47-2)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 16 h / 200 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 6 h / Reflux

3.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C

3.2: 6 h / Reflux

4.1: pyridinium chlorochromate / dichloromethane / 5 h / 0 - 20 °C / Molecular sieve

5.1: dichloromethane / 18 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere

7.1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 18 h / -25 °C / Molecular sieve

8.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

8.2: 3 h / 0 °C

8.3: 0.67 h / 0 - 20 °C

9.1: toluene-4-sulfonic acid / 0.5 h / 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

11.1: toluene-4-sulfonic acid; water / methanol / 12 h / Reflux

12.1: sodium periodate; water / methanol / 2 h / 0 °C

12.2: 1 h / 0 - 20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 9-borabicyclo[3.3.1]nonane; pyridinium chlorochromate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; decane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 1.1: Claisen Rearrangement / 5.1: Wittig Reaction / 7.1: Sharpless Epoxidation;

upstream raw materials:

4-methoxy-phenol

allyl (4-methoxyphenyl) ether

2-allyl-4-methoxyphenol

2-allyl-1-(benzyloxy)-4-methoxybenzene

Downstream raw materials:

(S)-(6-benzyloxy)-2-((cyclopropylmethoxy)methyl)chroman