N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

Base Information

Chemical Name:N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate
CAS No.:1428182-87-9
Molecular Formula:C₁₇H₁₂ClFN₆O₂S*ClH
Molecular Weight:455.3
Hs Code.:

Synonyms:N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

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Chemical Property of N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

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Technology Process of N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

There total 5 articles about N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428182-89-1
C₁₇H₉Cl₂FN₄O₂S

: 1428182-87-9
N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

Guidance literature:: C₁₇H₉Cl₂FN₄O₂S; With hydrazine; In water; isopropyl alcohol; at 20 - 120 ℃; for 0.333333h;

With trifluoroacetic acid; In water; acetonitrile;

With hydrogenchloride; In water;

Reference yield:

: 1428182-89-1
C₁₇H₉Cl₂FN₄O₂S

: 76-05-1
trifluoroacetic acid

: 1428182-87-9
N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

Guidance literature:: C₁₇H₉Cl₂FN₄O₂S; With hydrazine; In water; isopropyl alcohol; at 120 ℃; for 0.333333h; Microwave irradiation; Sealed tube;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/ml5003376

Reference yield:

: 351003-49-1
5-chloro-2-fluorobenzene-1-sulfonyl chloride

: 1428182-87-9
N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-nitro-4-trifluoromethylbenzenesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 h / 20 - 25 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 100 °C

3: hydrazine / water; isopropyl alcohol / 0.33 h / 20 - 120 °C

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate; hydrazine; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; 2: |Suzuki-Miyaura Coupling;