Technology Process of 2-oxo-5'-phenylindoline-3-spiro-2'-(1',3',4'-thiadiazol-4'-ine)
There total 9 articles about 2-oxo-5'-phenylindoline-3-spiro-2'-(1',3',4'-thiadiazol-4'-ine) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethanol;
at 40 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 68.3 percent / hydrazine hydrate (50 percent), aq.potassium hydroxide (1 N) / -6 - 0 °C
2: 53.7 percent / glacial acetic acid / heating on the boiling water bath, 10 min.
With
potassium hydroxide; hydrazine hydrate; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 12 h / Reflux
1.2: 12 h / 0 - 20 °C
2.1: sodium carbonate / tetrahydrofuran; water / 24 h / 20 °C
2.2: pH 2
3.1: hydrazine hydrate; sodium hydroxide / water / 2 h / 2 - 4 °C
3.2: 1 h / pH 2
4.1: ethanol / 12 h / 40 °C
With
hydrazine hydrate; iodine; sodium carbonate; magnesium; sodium hydroxide;
In
tetrahydrofuran; ethanol; water;
1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1016/j.cclet.2013.06.001