2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

Base Information

Chemical Name:2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride
CAS No.:1258853-04-1
Molecular Formula:C₂₇H₃₁N₅O₄*ClH
Molecular Weight:526.035
Hs Code.:

2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

Synonyms:2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

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Chemical Property of 2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

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Technology Process of 2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

There total 10 articles about 2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1258855-77-4
2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-((1R)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)acetamide

: 1258853-04-1
2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

Guidance literature:: 2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-((1R)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)acetamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258853-04-1
2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

4.1: potassium carbonate / acetonitirile / 20 - 60 °C / Inert atmosphere

5.1: sodium hydroxide / tetrahydrofuran; methanol / 28 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h / 20 °C

6.2: 16 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitirile; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258853-04-1
2-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]-N-[(1R)-2-hydroxy-1-methylethyl]acetamide monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3.1: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

5.1: potassium carbonate / acetonitirile / 20 - 60 °C / Inert atmosphere

6.1: sodium hydroxide / tetrahydrofuran; methanol / 28 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.03 h / 20 °C

7.2: 16 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitirile; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;