[1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene

Base Information

• Chemical Name: [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene
• CAS No.: 792959-66-1
• Molecular Formula: C₅₈H₁₁₆O₅Si₅
• Molecular Weight: 1033.98

Synonyms:[1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene

Chemical Property of [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene

There total 15 articles about [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide (81522-68-1) + (1R,3aR,7aR)-1-[(1R,4R)-4-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]-5-methyl-1-(4-methyl-4-(trimethylsilanyloxy)pentyl)-5-(trimethylsilanyloxy)hexyl]-7a-methyloctahydroinden-4-one (792959-65-0) → [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene (792959-66-1)

Guidance literature:

[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.166667h;

(1R,3aR,7aR)-1-[(1R,4R)-4-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]-5-methyl-1-(4-methyl-4-(trimethylsilanyloxy)pentyl)-5-(trimethylsilanyloxy)hexyl]-7a-methyloctahydroinden-4-one; In tetrahydrofuran; hexane; for 4h;

DOI:10.1021/jm049340b

Reference yield:

(2R)-2,3-dihydroxy-3-methylbutan-1-yl p-toluenesulfonate (77522-15-7) → [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene (792959-66-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 0.8586 g / BuLi / tetrahydrofuran; hexane / 6 h / -20 °C

2.1: sodium amalgam; MeOH / tetrahydrofuran / 14 h

2.2: 0.45 g / oxalic acid dihydrate / methanol

3.1: 85 percent / aq. fluorosilic acid / acetonitrile; dioxane / 3.25 h / 20 °C

4.1: pyridinium tosylate / acetone / 12 h / 20 °C

4.2: H₂O / 0.17 h

5.1: 0.3452 g / pyridine / 34 h / 20 - 35 °C

6.1: aq. AcOH / 2.5 h / Heating

7.1: imidazole / dimethylformamide / 48 h / 20 °C

7.2: 4-(N,N-dimethylamino)pyridine / dimethylformamide / 24 h

8.1: 0.3372 g / cyclohexane / 12 h

9.1: LiAlH₄ / tetrahydrofuran / 1.5 h

10.1: 0.2988 g / pyridinium dichromate; Celite / CH₂Cl₂ / 4.5 h

11.1: BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

11.2: 79 percent / hexane; tetrahydrofuran / 4 h

With pyridine; 1H-imidazole; methanol; sodium amalgam; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; Celite; fluorosilic acid; pyridinium p-toluenesulfonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone; acetonitrile; 11.2: Wittig-Horner reaction;

DOI:10.1021/jm049340b

Reference yield:

(1R,3aR,4S,7aR)-1-((S)-1-benzenesulfonylmethyl-5-methyl-5-trimethylsilanyloxyhexyl)-4-(tert-butyldimethylsilanyloxy)-7a-methyloctahydroindene (792959-54-7) → [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene (792959-66-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 0.8586 g / BuLi / tetrahydrofuran; hexane / 6 h / -20 °C

2.1: sodium amalgam; MeOH / tetrahydrofuran / 14 h

2.2: 0.45 g / oxalic acid dihydrate / methanol

3.1: 85 percent / aq. fluorosilic acid / acetonitrile; dioxane / 3.25 h / 20 °C

4.1: pyridinium tosylate / acetone / 12 h / 20 °C

4.2: H₂O / 0.17 h

5.1: 0.3452 g / pyridine / 34 h / 20 - 35 °C

6.1: aq. AcOH / 2.5 h / Heating

7.1: imidazole / dimethylformamide / 48 h / 20 °C

7.2: 4-(N,N-dimethylamino)pyridine / dimethylformamide / 24 h

8.1: 0.3372 g / cyclohexane / 12 h

9.1: LiAlH₄ / tetrahydrofuran / 1.5 h

10.1: 0.2988 g / pyridinium dichromate; Celite / CH₂Cl₂ / 4.5 h

11.1: BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

11.2: 79 percent / hexane; tetrahydrofuran / 4 h

With pyridine; 1H-imidazole; methanol; sodium amalgam; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; Celite; fluorosilic acid; pyridinium p-toluenesulfonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetone; acetonitrile; 11.2: Wittig-Horner reaction;

DOI:10.1021/jm049340b

upstream raw materials:

[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

(1R,3aR,7aR)-1-[(1R,4R)-4-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]-5-methyl-1-(4-methyl-4-(trimethylsilanyloxy)pentyl)-5-(trimethylsilanyloxy)hexyl]-7a-methyloctahydroinden-4-one

(2R)-2,3-dihydroxy-3-methylbutan-1-yl p-toluenesulfonate

(1R,3aR,4S,7aR)-1-{(R)-5-hydroxy-5-methyl-1-[2-((R)-2,2,5,5-tetramethyl-[1,3]dioxan-4-yl)ethyl]hexyl}-7a-methyloctahydroinden-4-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 792959-66-1 [1R,3aR,7aR,4E]-4-{2(Z)-[3(S),5(R)-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-1-[5-methyl-1(R)-(4-methyl-4-trimethylsilanyloxy-pentyl)-4(R)-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-trimethylsilanyloxy-hexyl]-octahydro-indene

Send

Send

Metric Ton KG G Pound L ML

Send

Send