(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

Base Information

Chemical Name:(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate
CAS No.:1447071-17-1
Molecular Formula:C₂₇H₃₇BrO₄
Molecular Weight:505.492
Hs Code.:

Synonyms:(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

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Chemical Property of (S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

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Technology Process of (S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

There total 3 articles about (S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1354491-92-1
7-bromo-3-methylnaphthalen-1-ol

: (1R)-(-)-menthyl glyoxylate

: 1447071-17-1
(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

Guidance literature:: 7-bromo-3-methylnaphthalen-1-ol; With titanium tetrachloride; In dichloromethane; at -40 ℃; for 0.333333h;

(1R)-(-)-menthyl glyoxylate; at -40 - 40 ℃; for 1.25h;

acetic acid tert-butyl ester; With perchloric acid; In water; for 3h;

Reference yield:

: 6186-22-7
4-bromophenyl acetone

: 1447071-17-1
(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 0 - 23 °C

2.1: sulfuric acid / 2.5 h / 50 °C

3.1: titanium tetrachloride / dichloromethane / 0.33 h / -40 °C

3.2: 1.25 h / -40 - 40 °C

3.3: 3 h

With sulfuric acid; titanium tetrachloride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 1354491-91-0
ethyl 4-(4-bromophenyl)-3-methylbut-2-enoate

: 1447071-17-1
(S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-2-(7-bromo-1-hydroxy-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 2.5 h / 50 °C

2.1: titanium tetrachloride / dichloromethane / 0.33 h / -40 °C

2.2: 1.25 h / -40 - 40 °C

2.3: 3 h

With sulfuric acid; titanium tetrachloride; In dichloromethane;