N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide
CAS No.:1290633-54-3
Molecular Formula:C₂₇H₃₂N₂O₇S₂
Molecular Weight:560.692
Hs Code.:

Synonyms:N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

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Chemical Property of N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

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Technology Process of N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

There total 5 articles about N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1290633-51-0
N-[(1S,2R)-6,7-dimethoxy-1-(5-propyl-thiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-nitrobenzenesulfonamide

: 107-30-2
chloromethyl methyl ether

: 1290633-54-3
N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

Guidance literature:: N-[(1S,2R)-6,7-dimethoxy-1-(5-propyl-thiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-nitrobenzenesulfonamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1039/c1cc10263j

Reference yield:

: C₁₈H₁₉BO₄

: 1290633-54-3
N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

1.2: 12 h / 0 °C / Reflux

2.1: copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole) / dichloromethane / 10 h / -25 °C / Molecular sieve; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) bis(trifluoromethanesulfonate); sodium hydride; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In tetrahydrofuran; dichloromethane; 1.1: Suzuki coupling / 2.1: Friedel Crafts alkylation;
DOI:10.1039/c1cc10263j

Reference yield:

: 4-[4-(3,4-dimethoxy-phenyl)but-1-enyl]-2-propylthiophene

: 1290633-54-3
N-[(1S,2R)-6,7-dimethoxy-1-(5-propylthiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methoxymethyl-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole) / dichloromethane / 10 h / -25 °C / Molecular sieve; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 0 - 20 °C

With copper(II) bis(trifluoromethanesulfonate); sodium hydride; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In tetrahydrofuran; dichloromethane; 1.1: Friedel Crafts alkylation;
DOI:10.1039/c1cc10263j