(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

Base Information

Chemical Name:(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile
CAS No.:1539314-90-3
Molecular Formula:C₁₃H₁₃ClN₂S
Molecular Weight:264.779
Hs Code.:

Synonyms:(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

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Chemical Property of (S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

Chemical Property:

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Technology Process of (S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

There total 3 articles about (S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 741658-04-8
(S)-1-methyl-2-methylsulfanylethylamine

: 1539314-89-0
2-chloro-4-fluoro-3-((trimethylsilyl)ethynyl)benzonitrile

: 1539314-90-3
(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 0.75h; Sealed tube;

Reference yield:

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: 1539314-90-3
(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 0.5 h / -70 °C / Cooling with ice

2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication

2.2: 41 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 100 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 899821-28-4
2-chloro-4-fluoro-3-iodobenzonitrile

: 1539314-90-3
(S)-2-chloro-3-ethynyl-4-((1-(methylthio)propan-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication

1.2: 41 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 100 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide;