trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

Base Information

Chemical Name:trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate
CAS No.:277751-15-2
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

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Chemical Property of trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

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Technology Process of trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

There total 3 articles about trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80656-13-9
trans-(1S,2S)-cyclopentane-1,2-dicarboxylic acid dimethyl ester

: 277751-15-2
trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / dioxane / 2 h / 20 °C

2: N-hydroxybenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; Et₃N / 20 °C / pH 8

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; 1: Hydrolysis / 2: Condensation;
DOI:10.1021/jm990557t

Reference yield:

: 192385-75-4
trans-(7S,8S)-1,4-dithiaspiro[4.4]nonane-7,8-dicarboxylic acid bis(methyl ester)

: 277751-15-2
trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Raney-Ni / methanol / 4 h / Heating

2: aq. NaOH / dioxane / 2 h / 20 °C

3: N-hydroxybenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; Et₃N / 20 °C / pH 8

With sodium hydroxide; nickel; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; 1: Desulfurization / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/jm990557t

Reference yield:

: 111138-48-8
(1S,2S)-2-methoxycarbonylcyclopentane-1-carboxylic acid

: benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate hydrochloride

: 277751-15-2
trans-methyl (1S,2S)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbonyl}cyclopentanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; at 20 ℃; pH=8;
DOI:10.1021/jm990557t