Technology Process of 5-bromo-2,3-dihydroxyphenylacetic acid
There total 11 articles about 5-bromo-2,3-dihydroxyphenylacetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminum tri-bromide;
In
benzene;
for 3h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / NaBH4 / propan-2-ol / 1 h / Heating
2: 83 percent / SOCl2 / diethyl ether / 2 h / Heating
3: 95 percent / various solvent(s) / 2 h / 100 °C
4: 75 percent / KOH / aq. ethanol / 10 h / Heating
5: 72 percent / AlBr3 / benzene / 3 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; thionyl chloride; aluminum tri-bromide;
In
diethyl ether; ethanol; isopropyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) NaNO2, conc. H2SO4, 2) copper powder, CuSO4*5H2O, NaBr, conc. H2SO4 / 1) water, 1-5 deg C, 2) water, reflux, 3 h, then distillation with steam
2: 51 percent / KMnO4 / H2O / 10 h / Heating
3: SOCl2 / 2 h / Heating
4: diethyl ether / 10 h / 20 °C
5: 57 percent / silver oxide / dioxane; H2O / 1 h / 95 °C
6: 72 percent / AlBr3 / benzene / 3 h / Heating
With
potassium permanganate; thionyl chloride; aluminum tri-bromide; sulfuric acid; copper; copper(II) sulfate; sodium bromide; silver(l) oxide; sodium nitrite;
In
1,4-dioxane; diethyl ether; water; benzene;
