C₂₁H₂₂Cl₂N₄O₃

Base Information

• Chemical Name: C₂₁H₂₂Cl₂N₄O₃
• CAS No.: 1227844-29-2
• Molecular Formula: C₂₁H₂₂Cl₂N₄O₃
• Molecular Weight: 449.337
• Mol file: 1227844-29-2.mol

Synonyms:C₂₁H₂₂Cl₂N₄O₃

Chemical Property of C₂₁H₂₂Cl₂N₄O₃

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₂₁H₂₂Cl₂N₄O₃

There total 1 articles about C₂₁H₂₂Cl₂N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-nitro-2-pent-4-ynyloxy-phenylamine (917501-64-5) + aniline mustard (553-27-5) → C21H22Cl2N4O3 (1227844-29-2)

Guidance literature:

4-nitro-2-pent-4-ynyloxy-phenylamine; With hydrogenchloride; In water;

With sodium nitrite; In water; at 0 - 5 ℃;

aniline mustard; In ethanol; water; at 0 - 5 ℃;

DOI:10.1002/anie.200906946

Reference yield: 97.9%

C21H22Cl2N4O3 (1227844-29-2) + C52H57N27O6 (1227844-31-6) → C136H145Cl8N43O18 (1227844-32-7)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; ascorbic acid; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.200906946

Reference yield:

C21H22Cl2N4O3 (1227844-29-2) + N,N-bis(2-azidoethyl)aniline (99169-09-2) → C52H57N27O6 (1227844-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; ascorbic acid / tetrahydrofuran; water / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 80 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; ascorbic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201200441

upstream raw materials:

4-nitro-2-pent-4-ynyloxy-phenylamine

aniline mustard

Downstream raw materials:

C₁₃₆H₁₄₅Cl₈N₄₃O₁₈

C₅₂H₅₇N₂₇O₆