3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene

Base Information

• Chemical Name: 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene
• CAS No.: 1187567-15-2
• Molecular Formula: C₂₉H₂₇BrClNO₃
• Molecular Weight: 552.895
• Mol file: 1187567-15-2.mol

Synonyms:3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene

Chemical Property of 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene

There total 1 articles about 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

E/Z-1,3-Dichloropropene (542-75-6) + 1-(benzyloxy)-4-bromo-3-((tert-butyloxycarbonyl)-amino)phenanthrene (1187567-14-1) → 3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene (1187567-15-2)

Guidance literature:

1-(benzyloxy)-4-bromo-3-((tert-butyloxycarbonyl)-amino)phenanthrene; With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

E/Z-1,3-Dichloropropene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Darkness;

DOI:10.1016/j.tet.2009.02.065

Reference yield: 48.0%

3-[N-(tert-butyloxycarbonyl)-N-(3-chloroprop-2-en-1-yl)amino]-1-(benzyloxy)-4-bromophenanthrene (1187567-15-2) → 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydronaphtho[1,2-e]indole (1187567-16-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2009.02.065

upstream raw materials:

E/Z-1,3-Dichloropropene

1-(benzyloxy)-4-bromo-3-((tert-butyloxycarbonyl)-amino)phenanthrene

Downstream raw materials:

5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydronaphtho[1,2-e]indole