N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine

Base Information

• Chemical Name: N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine
• CAS No.: 1421372-06-6
• Molecular Formula: C₂₄H₂₇ClN₈O
• Molecular Weight: 478.984
• Mol file: 1421372-06-6.mol

Synonyms:N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine

Chemical Property of N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine

There total 7 articles about N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-chloro-N-[4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-2-methoxy-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine (1421372-07-7) → N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine (1421372-06-6)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 1.5h; Reflux;

Reference yield:

5-chloro-N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine (1421372-08-8) → N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine (1421372-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; water;

Reference yield:

3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (1224709-13-0) → N-{5-chloro-(4-pyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl}-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-6-methoxybenzene-1,3-diamine (1421372-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 18 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

3: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; water;

upstream raw materials:

5-chloro-N-[4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-2-methoxy-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

5-chloro-N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine

4-[(E)-2-butoxyethenyl]-2,5-dichloropyrimidine

Downstream raw materials:

2-({5-amino-4-[(3R)-3-dimethylaminopyrrolidin-1-yl]-2-methoxyphenyl}amino)-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidine-5-carbonitrile

N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[(3R)-3-dimethylaminopyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

C₂₈H₂₉N₉O₂