2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide

Base Information

• Chemical Name: 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide
• CAS No.: 1325217-49-9
• Molecular Formula: C₂₂H₃₅N₃O₅
• Molecular Weight: 421.537
• Mol file: 1325217-49-9.mol

Synonyms:2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide

Chemical Property of 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide

There total 7 articles about 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(benzyloxy)-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide (1355069-04-3) → 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide (1325217-49-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 3.5h;

DOI:10.1002/ejoc.201100443

Reference yield:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide (1027755-54-9) → n-dioctylamine (1120-48-5) + N,N-dioctylacetamide (4088-41-9) + N,N’-dioctyl-α-hydroxy acetamide (440339-85-5) + 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide (1325217-49-9) + 2-[2-(3-formylbenzylamino)-2-oxoethoxy]-N,N-dioctylacetamide (1325217-44-4) + 2-{2-[3-(aminomethyl)benzylamino]-2-oxoethoxy}-N,N-dioctylethanamide (1325217-51-3) + 2-{2-[3-(acetamidomethyl)benzylamino]-2-oxoethoxy}-N,N-dioctylacetamide (1325217-41-1) + 2-(2-{3-[(2-hydroxyacetamido)methyl]benzylamino}-2-oxoethoxy)-N,N-dioctylacetamide (1325217-52-4) + N,N-dioctyl-2-{2-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzylamino]-2-oxoethoxy}acetamide (1325217-45-5) + 2-(2-(di-octylamino)-2-oxoethoxy)acetic acid (135447-09-5)

Guidance literature:

In dodecane; octanol; Irradiation;

DOI:10.1002/ejoc.201100443

Reference yield:

2-[2-(octylamino)-2-oxoethoxy]acetic acid (904794-18-9) → 2-hydroxy-N-[3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzyl]acetamide (1325217-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 36 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol / 3.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1002/ejoc.201100443

upstream raw materials:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide

2-[2-(octylamino)-2-oxoethoxy]acetic acid

tert-butyl 3-({2-[2-(octylamino)-2-oxoethoxy]acetamido}methyl)benzylcarbamate

N-[3-(aminomethyl)benzyl]-2-[2-(octylamino)-2-oxoethoxy]ethanamide