2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

Base Information

Chemical Name:2,8-dimethyl-6-benzyloxychroman-2-methanol triflate
CAS No.:951404-41-4
Molecular Formula:C₂₀H₂₁F₃O₅S
Molecular Weight:430.445
Hs Code.:

Synonyms:2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

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Chemical Property of 2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

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Technology Process of 2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

There total 9 articles about 2,8-dimethyl-6-benzyloxychroman-2-methanol triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 951404-35-6
2,8-dimethyl-6-benzyloxychroman-2-methanol

: 358-23-6
trifluoromethylsulfonic anhydride

: 951404-41-4
2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

Guidance literature:: With pyridine; for 2h;
DOI:10.1021/jo0705418

Reference yield:

: 951404-31-2
methyl 2,8-dimethyl-6-benzoyloxychroman-2-carboxylate

: 951404-41-4
2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / lithium aluminium hydride / diethyl ether

2.1: PS-30 lipase on hyflosupercell / various solvent(s) / 5 h / 20 °C

2.2: aq. LiOH / methanol; tetrahydrofuran / 0.33 h

2.3: PS-30 lipase on hyflosupercell / various solvent(s) / 5 h / 20 °C

3.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h

4.1: 73 percent / K₂CO₃ / dimethylformamide / 12 h

5.1: 95 percent / pyridine / 2 h

With pyridine; lithium hydroxide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo0705418

Reference yield:

: 951404-33-4
2,8-dimethyl-6-hydroxychroman-2-methanol

: 951404-41-4
2,8-dimethyl-6-benzyloxychroman-2-methanol triflate

Guidance literature:: Multi-step reaction with 4 steps

1.1: PS-30 lipase on hyflosupercell / various solvent(s) / 5 h / 20 °C

1.2: aq. LiOH / methanol; tetrahydrofuran / 0.33 h

1.3: PS-30 lipase on hyflosupercell / various solvent(s) / 5 h / 20 °C

2.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h

3.1: 73 percent / K₂CO₃ / dimethylformamide / 12 h

4.1: 95 percent / pyridine / 2 h

With pyridine; lithium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo0705418