(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester
CAS No.:202416-36-2
Molecular Formula:C₁₄H₂₃BrO₅Si
Molecular Weight:379.323
Hs Code.:

Synonyms:(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of (4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

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Technology Process of (4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

There total 3 articles about (4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 202416-35-1
(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-3-oxo-5-(2,2,2-trifluoro-acetoxy)-cyclohex-1-enecarboxylic acid methyl ester

: 202416-36-2
(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; for 2h; Ambient temperature;
DOI:10.1021/jo971858i

Reference yield:

: 189366-38-9
(1S,2R,4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-6-oxa-bicyclo[3.2.1]octane-3,7-dione

: 202416-36-2
(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / MeONa / 0.25 h

2: 90 percent / pyridine; CH₂Cl₂ / 2 h / Ambient temperature

3: 81 percent / K₂CO₃ / H₂O; tetrahydrofuran / 2 h / Ambient temperature

With sodium methylate; potassium carbonate; In tetrahydrofuran; pyridine; dichloromethane; water;
DOI:10.1021/jo971858i

Reference yield:

: 202416-32-8
(1S,2R,4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1,5-dihydroxy-3-oxo-cyclohexanecarboxylic acid methyl ester

: 202416-36-2
(4S,5R)-2-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine; CH₂Cl₂ / 2 h / Ambient temperature

2: 81 percent / K₂CO₃ / H₂O; tetrahydrofuran / 2 h / Ambient temperature

With potassium carbonate; In tetrahydrofuran; pyridine; dichloromethane; water;
DOI:10.1021/jo971858i