(6b)-6-Bromoandrost-4-ene-3,17-dione

Base Information

Chemical Name:(6b)-6-Bromoandrost-4-ene-3,17-dione
CAS No.:38632-00-7
Molecular Formula:C19H25BrO2
Molecular Weight:365.31
Hs Code.:
Mol file:38632-00-7.mol

Synonyms:Androst-4-ene-3,17-dione,6b-bromo- (7CI);6b-Bromoandrost-4-ene-3,17-dione;6b-Bromoandrostenedione;

Suppliers and Price of (6b)-6-Bromoandrost-4-ene-3,17-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6β-BromoAndrostenedione
10mg
$ 175.00

Chemenu
6b-Bromoandrost-4-ene-3,17-dione 95%
25g
$ 234.00

Chemenu
6b-Bromoandrost-4-ene-3,17-dione 95%
100g
$ 636.00

American Custom Chemicals Corporation
6-BRONMANDROSTENEDIONE 95.00%
5MG
$ 499.57

Total 103 raw suppliers

Chemical Property of (6b)-6-Bromoandrost-4-ene-3,17-dione

Chemical Property:

Vapor Pressure:6.77E-09mmHg at 25°C
Melting Point:158-163°C (dec.)
Refractive Index:1.577
Boiling Point:467 °C at 760 mmHg
Flash Point:100.3 °C
PSA：34.14000
Density:1.35 g/cm³
LogP:4.46080
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Methanol (Very Slightly. Heated. Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

6β-BromoAndrostenedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description (6b)-6-Bromoandrost-4-ene-3,17-dione is a brominated steroid derivative that serves as a key intermediate in the synthesis of modified androgens and potential aromatase inhibitors. It exists as a 6β-bromo epimer, which can undergo epimerization to the 6α-isomer under specific conditions, such as in carbon tetrachloride or chloroform-methanol mixtures. (6b)-6-Bromoandrost-4-ene-3,17-dione exhibits instability in methanol, leading to decomposition into 5α-androstane-3,6-dione derivatives. Additionally, it has been explored for its role in irreversible inactivation of human placental aromatase and as a substrate in Suzuki-Miyaura cross-coupling reactions to generate 6-arylated steroids, highlighting its utility in medicinal chemistry and steroid modification.

Technology Process of (6b)-6-Bromoandrost-4-ene-3,17-dione

There total 8 articles about (6b)-6-Bromoandrost-4-ene-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 63-05-8
Androstenedione

: 38632-00-7,61145-67-3,64395-40-0
(8R,9S,10R,13S,14S)-6-bromo-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[α]phenanthrene-3,17(2H,6H)-dione

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; water; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c2cc31973j