2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline

Base Information

• Chemical Name: 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline
• CAS No.: 1289486-04-9
• Molecular Formula: C₂₆H₂₈ClNO₃
• Molecular Weight: 437.966

Synonyms:2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline

Chemical Property of 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline

Chemical Property:

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Technology Process of 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline

There total 8 articles about 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(benzyloxy)-4-chloroaniline + 4-(3-(bromomethyl)phenyl)-4-methoxytetrahydro-2H-pyran (144800-91-9) → 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline (1289486-04-9)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.bmc.2011.01.043

Reference yield:

2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione (1289485-42-2) → 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline (1289486-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: water; hydrazine / ethanol / 2 h / Reflux

3: potassium carbonate / acetone / Reflux

With water; potassium carbonate; hydrazine; In ethanol; acetone;

DOI:10.1016/j.bmc.2011.01.043

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 2-(benzyloxy)-4-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl) benzyl) aniline (1289486-04-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / Reflux

1.2: 1 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1.5 h / Reflux

4.1: potassium carbonate / acetone / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; magnesium; In tetrahydrofuran; tetrachloromethane; acetone; mineral oil;

DOI:10.1016/j.bmc.2011.01.043

upstream raw materials:

Tetrahydro-4H-pyran-4-one

2-(4-chloro-2-hydroxyphenyl)isoindoline-1,3-dione

C₂₁H₁₄ClNO₃

meta-bromotoluene

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