2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

Base Information

Chemical Name:2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide
CAS No.:332081-76-2
Molecular Formula:C₂₅H₃₀ClNO₅
Molecular Weight:459.97
Hs Code.:

Synonyms:2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

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Chemical Property of 2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

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Technology Process of 2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

There total 1 articles about 2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 97322-68-4
Ethyl 3-<4-<(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>phenyl>-2-chloropropionate

: 332081-76-2
2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

Guidance literature:: With ammonia; In methanol; for 1.5h; heating;
DOI:10.1021/tx000180q

Reference yield: 85.0%

: 332081-76-2
2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

: 332081-77-3
2-chloro 3-{4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

Guidance literature:: With sodium methylate; sodium hydride; In methanol; at 20 ℃; for 2h;
DOI:10.1021/tx000180q

Reference yield:

: 332081-76-2
2-chloro 3-{4-[(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)metoxy]phenyl}propanamide

: 2-amino-4-(N-{1-[N-(2,2-dihydroxyethyl)carbamoyl]-2-[(1-carbamoyl-2-{4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]phenyl}ethyl)disulfanyl]ethyl}carbamoyl)-butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / CH₃ONa; NaH / methanol / 2 h / 20 °C

2.1: hexamethyldisilathiane; tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 40 °C

2.2: 10 percent / aq. NaHCO₃ / tetrahydrofuran / 20 h / 40 °C

With hexamethyldisilathiane; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/tx000180q