5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

Base Information

Chemical Name:5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid
CAS No.:1436871-90-7
Molecular Formula:C₂₆H₁₈Cl₂O₂
Molecular Weight:433.334
Hs Code.:

Synonyms:5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

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Chemical Property of 5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

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Technology Process of 5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

There total 3 articles about 5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1436872-15-9
methyl 5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoate

: 1436871-90-7
5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 90 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/ja402910d

Reference yield:

: 101-41-7
benzeneacetic acid methyl ester

: 1436871-90-7
5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 0 °C / Inert atmosphere; Schlenk technique

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere; Schlenk technique

3.1: lithium hydroxide; water / tetrahydrofuran / 90 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; sodium hydride; triethylamine; lithium hydroxide; In tetrahydrofuran; mineral oil; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1021/ja402910d

Reference yield:

: 22489-95-8
2-phenyl-2-prop-2-ynylpent-4-ynoic acid methyl ester

: 1436871-90-7
5-(4-chlorophenyl)-2-(3-(4-chlorophenyl)prop-2-ynyl)-2-phenylpent-4-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere; Schlenk technique

2: lithium hydroxide; water / tetrahydrofuran / 90 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/ja402910d