2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Base Information

Chemical Name:2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
CAS No.:110464-25-0
Molecular Formula:C₂₂H₂₆Cl₂N₄O₆
Molecular Weight:513.378
Hs Code.:

Synonyms:2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

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Chemical Property of 2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

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Technology Process of 2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

There total 4 articles about 2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110464-40-9
2-<<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrid-2-yl>methoxy>methyl>-2-methyloxirane

: 110464-25-0
2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Guidance literature:: With sodium azide; magnesium(II) perchlorate; In 1,4-dioxane; water; for 60h; Ambient temperature;
DOI:10.1021/jm00105a004

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 110464-25-0
2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / HgSO₄, conc. H₂SO₄ / dioxane; H₂O / 2 h / 60 °C

2: 44 percent / cetyltrimethylammonium bromide, 5 M aq. NaOH / 1,1,1-trichloro-ethane / 1.67 h / 60 - 65 °C

3: 88 percent / NaN₃, Mg(ClO₄)2 / dioxane; H₂O / 60 h / Ambient temperature

With sodium hydroxide; sodium azide; magnesium(II) perchlorate; sulfuric acid; cetyltrimethylammonim bromide; mercury(II) sulfate; In 1,4-dioxane; 1,1,1-trichloroethane; water;
DOI:10.1021/jm00105a004

Reference yield:

: 101411-57-8
4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<(2-oxopropoxy)methyl>-1,4-dihydropyridine

: 110464-25-0
2-<(3-azido-2-hydroxy-2-methylpropoxy)methyl>-4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / cetyltrimethylammonium bromide, 5 M aq. NaOH / 1,1,1-trichloro-ethane / 1.67 h / 60 - 65 °C

2: 88 percent / NaN₃, Mg(ClO₄)2 / dioxane; H₂O / 60 h / Ambient temperature

With sodium hydroxide; sodium azide; magnesium(II) perchlorate; cetyltrimethylammonim bromide; In 1,4-dioxane; 1,1,1-trichloroethane; water;
DOI:10.1021/jm00105a004