cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

Base Information

Chemical Name:cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one
CAS No.:180624-34-4
Molecular Formula:C₂₀H₂₀BrNO₂
Molecular Weight:386.288
Hs Code.:

Synonyms:cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

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Chemical Property of cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

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Technology Process of cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

There total 3 articles about cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 147145-09-3
(4bS,7R,9aS)-4-Bromo-7-phenyl-4b,5,7,8,10,11-hexahydro-9-oxa-6a-aza-pentaleno[1,6a-a]naphthalen-6-one

: 180624-34-4
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

Guidance literature:: (4bS,7R,9aS)-4-Bromo-7-phenyl-4b,5,7,8,10,11-hexahydro-9-oxa-6a-aza-pentaleno[1,6a-a]naphthalen-6-one; With triethylsilane; In dichloromethane; at -78 ℃; for 0.25h;

With titanium tetrachloride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo960185l

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 180624-34-4
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / toluene / 19 h / Heating

2.1: triethylsilane / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 80 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

With triethylsilane; In dichloromethane; toluene; 1.1: Condensation / 2.1: Reduction / 2.2: desilylation;
DOI:10.1021/jo960185l

Reference yield:

: (8-bromo-2-oxo-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid ethyl ester

: 180624-34-4
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / toluene / 19 h / Heating

2.1: triethylsilane / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 80 percent / TiCl₄ / CH₂Cl₂ / 2 h / -78 °C

With triethylsilane; In dichloromethane; toluene; 1.1: Condensation / 2.1: Reduction / 2.2: desilylation;
DOI:10.1021/jo960185l