5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine
CAS No.:1404513-42-3
Molecular Formula:C₃₄H₃₃N₅O₉
Molecular Weight:655.664
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

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Technology Process of 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

There total 4 articles about 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 1404513-42-3
5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0 - 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 6 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

4: ammonium hydroxide / 1,4-dioxane / 24 h / 20 °C

5: pyridine / 15 h / 20 °C

With pyridine; ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201201960

Reference yield:

: 58589-18-7
3',5'-di-O-acetyl-5-bromomethyl-2'-deoxyuridine

: 1404513-42-3
5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2: ammonium hydroxide / 1,4-dioxane / 24 h / 20 °C

3: pyridine / 15 h / 20 °C

With pyridine; ammonium hydroxide; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201201960

Reference yield:

: 6979-97-1,97834-40-7,142405-86-5
3',5'-diacetylthymidine

: 1404513-42-3
5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 6 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3: ammonium hydroxide / 1,4-dioxane / 24 h / 20 °C

4: pyridine / 15 h / 20 °C

With pyridine; ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201201960