3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

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Chemical Name:3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile
CAS No.:1339889-74-5
Molecular Formula:C₂₉H₃₃N₇
Molecular Weight:479.628
Hs Code.:

Synonyms:3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

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Chemical Property of 3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

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Technology Process of 3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

There total 9 articles about 3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.19%

: 1339892-19-1
7-(4-(1-methylpiperidin-4-yl)phenyl)-5-(1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine

: 591769-05-0
3-cyclopentyl-acrylonitrile

: 1339889-74-5
3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 66h;

Reference yield:

: 769944-78-7
tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate

: 1339889-74-5
3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere

2.1: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / isopropyl alcohol / 54 h / 90 °C / Inert atmosphere

2.3: pH 9

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / ISOPROPYLAMIDE; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.1: N,N-diethylaniline; trichlorophosphate / 4 h / 50 °C / Inert atmosphere

5.2: Cooling with ice

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / 100 °C / Inert atmosphere

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 66 h / 20 °C

With potassium phosphate; water; sodium tris(acetoxy)borohydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; N,N-diethylaniline; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1339892-13-5
7-(4-(piperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-ol

: 1339889-74-5
3-cyclopentyl-3-(4-(7-(4-(1-methylpiperidin-4-yl)phenyl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / ISOPROPYLAMIDE; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: N,N-diethylaniline; trichlorophosphate / 4 h / 50 °C / Inert atmosphere

2.2: Cooling with ice

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / 100 °C / Inert atmosphere

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 66 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;